Safely Eliminate Tissue Waste

Tissue Digestor

Tissue digesters are engineered systems designed to safely and effectively process biological tissues through controlled thermal and chemical conditions. Configuration choices are driven by containment requirements, throughput, utility availability, and downstream discharge constraints.

BioSAFE Tissue Digester system during installation.

Engineered for Safe Tissue Waste Processing

Tissue Digesters are designed to safely and efficiently process tissue waste, using patented alkaline hydrolysis technology to reduce the risk of contamination and minimize environmental impact.
Tissue Digesters are used in:

  • Agricultural research and testing facilities
  • Biopharmaceutical research
  • Facilities, including high-security BSL-3 and BSL-4 containment facilities
  • Prion waste
  • Pathological waste

High Pressure vs Low Pressure

Tissue digesters may operate under either high-pressure or low-pressure conditions. Each approach represents a different balance between treatment intensity, cycle time, capital cost, and operational complexity.

High pressure 

High-pressure digesters achieve rapid and highly effective tissue breakdown through elevated temperature and pressure. This configuration enables shorter cycle times and delivers the highest level of treatment efficacy, making it well suited for demanding research or containment environments.

  •  Highest level of efficacy 
  •  Faster cycle times 

Low pressure 

Low-pressure digesters operate at reduced system pressures while still providing reliable tissue processing. This approach lowers capital cost and mechanical complexity, making it an attractive option for facilities with moderate throughput or less stringent processing demands.

  •  Lower capital cost 

Mechanically Agitated Thermic Digester vs Caustic Digester

Tissue digesters may employ either mechanically agitated thermic processing or chemically driven caustic digestion. The appropriate technology depends on containment strategy, utility costs, chemical handling preferences, and validation requirements,.

Mechanically Agitated Thermic Digester (MATD)

MATD systems use heat and mechanical agitation to accelerate tissue breakdown while minimizing chemical usage. This design reduces utility and sewer demand while allowing flexibility for either wet or dry discharge. The result is an efficient, adaptable system suited for a wide range of operational environments. 

  • Less chemical demand
  • Lower utility cost 
  • Dry or wet discharge 
  • Lower sewer demand 

Caustic Digester 

Caustic digesters rely on alkaline chemistry to achieve controlled tissue dissolution within a closed system. These systems are particularly well suited for containment applications, offering built-in redundancy and a long track record of proven performance in regulated facilities.

  •  Ideal for containment applications 
  • Redundancy in design and critical components 
    • Time tested design 

Wet vs Dry Discharge

Digesters may be configured to discharge treated material in either wet or dry form. The selection impacts downstream handling, sewer demand, chemical consumption, and overall cycle time.

Wet 

Wet discharge systems eliminate the need for post-process solids handling by discharging directly to the sanitary system. This approach reduces chemical usage and enables shorter processing cycles, simplifying day-to-day operation.

  •  No post process handling 
  • Less chemical used 
  • Shorter cycle times 

Dry 

Dry discharge systems separate and retain solids following digestion, significantly reducing sewer loading. This configuration is well suited for facilities with limited sewer capacity or stricter discharge constraints.

  •  Lower sewer demand 

Building Integrated Containment or Standalone

Tissue digesters can be deployed as part of a building-integrated containment strategy or as standalone units. Each option supports safe operation while addressing different facility layouts and budget considerations.

Building integrated 

Building-integrated digesters are designed to interface directly with containment spaces, enabling seamless tissue disposal without breaching controlled environments. This approach is ideal for high-containment or high-throughput facilities where operational continuity is critical.

  • Ideal for containment applications 
  • Allows for seamless disposal from within containment 

Stand alone 

Standalone digesters offer a cost-effective solution with a smaller physical footprint. They are well suited for facilities seeking reliable tissue processing without extensive building integration or containment modifications.

  •  Lower capital cost 
  • Smaller footprint 

Tissue digesters provide a controlled, validated method for the safe processing and disposal of biological tissues generated in research, clinical, and containment environments. These systems are designed to manage complex biological materials while maintaining operator safety, process reliability, and compliance with facility requirements.

Our tissue digester offerings span multiple operating pressures, digestion technologies, and discharge configurations, allowing each system to be matched precisely to its intended application. From high-efficacy, high-pressure systems to lower-cost, low-pressure alternatives, each design prioritizes dependable performance and predictable outcomes.

Whether deployed as a standalone unit or integrated directly into a containment space, these digesters support seamless workflows and long-term operational stability. By combining proven digestion methods with modern engineering and redundancy where it matters most, our systems deliver confidence in even the most demanding environments.

How It Works

  1. Tissue matter is loaded into the top hatch of the Tissue Digester via hoist or crane (depending on the unit size).
  2. The system is sealed for operator safety and pressurized.
  3. The material undergoes BioSAFE’s patented alkaline hydrolysis digestion process, reducing 97% of tissue to sterilized effluent material that can be released into the sanitary sewer.

Remaining byproducts are sterilized inorganic matter (such as calcium phosphate from bones and teeth, gloves, etc.).


Tissue Digesters Built to Your Needs

Like all BioSAFE products, Tissue Digesters can be customized to your facility’s needs and are available in sizes ranging from 5 pounds to 10,000 pounds per cycle. Standard features include:


  • Uses patented alkaline hydrolysis process
  • Reduces 97% of tissue waste
  • Eliminates most toxins without creating new ones (unlike incineration)
  • Generates no unsafe byproducts or emissions.

Patented Alkaline Hydrolysis Technology

BioSAFE’s patented alkaline hydrolysis technology is designed for the world’s most hazardous, infectious, and critical disposal challenges—converting potentially infectious tissue waste into sterile effluent.
Our equipment is in service worldwide, from non-containment sites to highly infectious BSL-3 (Ag) and BSL-4 laboratories.


Applications include:

  • Disposal of infected animal tissue and carcasses in agricultural research facilities
  • Decontamination of human tissue used in biopharmaceutical research
  • Safe, compliant tissue waste disposal with no smokestack, no emissions, and no negative environmental impact
BioSAFE Tissue Digester being installed for agricultural research applications.

Compliant, Safe, and Efficient Tissue Waste Disposal for Agricultural Research Facilities

BioSAFE Tissue Digesters are designed to support the strict waste management standards required at every biosafety level. Our patented alkaline hydrolysis process ensures the safe destruction of GMO organisms, bioengineered materials, genetically modified tissue, and other high-risk waste, without harmful emissions. For agricultural research labs, including BSL-3Ag facilities, this technology is critical for safely disposing of infected carcasses, prion risk material, and pathogens like foot-and-mouth disease or chronic wasting disease.

BioSAFE provides a safer, compliant, and cost-effective alternative trusted worldwide.

Trusted Worldwide by Industry Leaders

Effective Treatment of Prion Risk Material (PRM)

Certain diseases, such as chronic wasting disease (CWD) and other prion-related conditions, present unique challenges for safe disposal. Unlike bacteria or viruses, prions are misfolded proteins that are resistant to traditional sterilization methods, making them especially dangerous if not handled properly. BioSAFE Tissue Digesters are one of the few proven technologies capable of destroying prion risk material (PRM) through patented alkaline hydrolysis. This process breaks down infectious tissue at the molecular level, ensuring prions are neutralized and eliminating the risk of environmental contamination. With BioSAFE, you can protect your facility, your community, and the environment from the spread of prion diseases like CWD.
BioSAFE Tissue Digester being installed for agricultural research applications.

Tissue Digester FAQs

Find answers to common questions about the Tissue Digester, including maintenance, installation requirements, and safety measures.

Accordion Content

Any facility generating regulated tissue waste should have a method of safe disposal. BioSAFE’s alkaline-hydrolysis tissue digesters are trusted by agricultural research facilities including BSL-3 and BSL-4 worldwide.

BioSAFE alkaline hydrolysis Tissue Digester are available capacities from 5 to 10,000 lbs per cycle with a typical cycle time of approximately 60 minutes.

BioSAFE’s Tissue Digesters are designed for easy maintenance. It features automated cleaning and self-diagnostic capabilities, reducing the need for manual intervention. We also provide comprehensive support and maintenance services.

Alkaline hydrolysis destroys all protein based materials, including:

  • Human and animal tissues
  • Bacteria, viruses, and fungi
  • Bio-engineered products, recombinant DNA organisms, viral vectors
  • Prions and prion infected material, including bovine spongiform encephalopathy (Mad Cw disease), chronic wasting disease (zombie deer disease), and scrapie.

While incinerators and Tissue Digesters perform largely the same function (decontamination and destruction of contaminated tissue material), they differ substantially in operating cost and environmental impact. Incinerators can have operating costs in excess of $0.75 per pound depending on age of the unit, energy costs and regulations in the area.

Operators are also exposed to ash, dust, and toxic gases during the operation of an incinerator and heavy regulations are in place around emissions compliance. Tissue Digesters typically operate at a cost of between $0.03 and $0.12 per pound and are considered a closed-loop system, eliminating operator exposure to harmful chemicals and pathogens during the decontamination process. Tissue Digesters also produce no harmful by-products during operation.

Eliminate Tissue Waste at the Lowest Operating Costs in the Industry

Contact our sales team to see what type of tissue digester your facility needs.